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KMID : 0829220140380060349
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Korean Journal of Oral and Maxillofacial Pathology
2014 Volume.38 No. 6 p.349 ~ p.356
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The Expression of NF-κB p65 Protein in Oral Squamous Cell Carcinoma from Korean Oral Cancer Patients
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Han Hye-Yeon
Park Won-Ick
Jeong Su-Min
Jang Hye-Ock
Bae Soo-Kyung
Ryu Mi-Heon
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Abstract
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Oral squamous cell carcinoma (OSCC), is the most common malignancy of oral cavity, and the sixth most frequently diagnosedcancer worldwide. This tumor type is associated with poor prognosis, and most OSCC patients are diagnosed after the cancer hasreached an advanced stage. The over expression of NF-κB p65 has been associated with OSCC progression and lymph node metastasis.
Hence, the present study analyzed the expression of NF-κB p65 in OSCC from Korean patients. Immunohistochemistry for NF-κBp65 was performed using 12 normal oral mucosas (NOM), 16 oral leukoplakia (with/without dysplasia), and 58 OSCC patients samples.
Immunoreactivity was semi-quantitatively scored and the correlation between the expression of NF-κB p65 and clinicopathologicalparameters of OSCC patients was analyzed. Immunohistochemical staining revealed that NF-κB p65 expression level increased in oralleukoplakia with dysplasia and OSCC. Moreover, the immunoexpression of NF-κB p65 appeared to be associated with age, recurrence,TNM stage, and lymph node metastasis in OSCC patients (p<0.05). These results indicated that NF-κB p65 can play a role as oncogenein OSCC. Moreover, NF-κB p65 may play an important role in both oral carcinogenesis and OSCC patient outcome. It may be consideredas another new malignant biomarker of OSCC.
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KEYWORD
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Oral squamous cell carcinoma, NF-κB p65, oncogene, Biomarker
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